Chemical Biology and Drug Discovery for Oncology Indications

Prezentacja na temat: "Chemical Biology and Drug Discovery for Oncology Indications"— Zapis prezentacji:

1 Chemical Biology and Drug Discovery for Oncology Indications
Tad Holak Chemical Biology and Drug Discovery for Oncology Indications Organic Chemistry, Jagiellonian University, Kraków, Poland Malopolskie Center for Biotechnology UJ, Kraków, Poland Organic compounds X-ray structures Cell activity

2 X-ray structure of the protein-protein complex
synthesis X-ray structures: compound-protein Check by NMR if the compound dissociates the protein-protein complex

3 Small-molecule compounds for targeting protein-protein interactions for non-genotoxic therapy of cancer

4 Releasing p53 from its MDM2 inhibition –
to carry out its anti-tumor duties in tumor cells 50% antagonist 50%

5 Collaborations

6 Molecular biology Organic chemistry NMR Jacek Otlewski Wrocław
Grzegorz Dubin Kraków Organic chemistry NMR Alexander Dömling Groningen NL T. Holak Kraków

7 Current group members

8 The group Postdocs: PhD students: Dr. Bogdan Musielak
Dr. Łukasz Skalniak Dr. Bartek Zięba Dr. Ewa Wrona PhD students: Marcin Tomala Marcin Pustuła Sylwia Krzanik Dobrosława Krzemień Aleksandra Twarda Radosław Kitel Katarzyna Guzik Katarzyna Kubica Mirosława Czub Katarzyna Magiera Krzysztof Żak

9 MSc students: Paulina Topór   Beata Łabuzek   Dominik Sala Oliwia Matuszewska Damian Muszak Diana Karwicka Justyna Polak Justyna Kocik Katarzyna Sitarz